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Azoturia or Equine Rhabdomyelosis, is a condition that affects the muscles of horses, ranging from stiffness and mild cramps to the horse becoming unable to stand with discoloured urine
Terminology
Monday Morning Disease, Tying-Up, Azoturia, Paralytic Myoglobinuria, Myositis and Setfast
Causes
The basic mechanism of the disease is poorly understood and it is likely that the predisposing and triggering factor(s) are slightly different for each animal. Possible predisposing factors include:
- Carbohydrate Overloading -The classical presentation is the draught horse in work that is rested or the weekend on full feed, then when the horse returns to work several days later it suffers an attack of the disease. It is thought that muscle glycogen accumulates during the rest period and when used during exercise it produces excessive lactic acid. This causes local tissue damage and constriction of the blood vessels, resulting in decreased blood flow to the tissues and further reduction in lactic acid removal.
- Local Hypoxia - Certain types of muscle fibres are larger, have greater glycogen stores and fewer surrounding blood vessels than others. Local hypoxia (lack of oxygen supplied by the blood) may increase the lactic acid production in these fibres. However equine rhabdomyelosis normally occurs at the start of exercise, when these fibres would not yet be working and the condition is not usually seen in horses with other conditions causing impaired circulation
- Thiamine Deficiency - Thiamine (one of the B Group of Vitamins) acts in the metabolism of waste products from muscle activity. A deficiency, therefore, could lead to a build up of these waste products and hence, lactic acid.
- Vitamin E and Selenium Deficiency - This theory is based on reports of success at preventing further episodes following supplementation. Clinical trials have failed to confirm this.
- Hormonal Disturbances - Reproductive hormones, thyroid hormones and cortisol have all been implicated in equine rhabdomyelosis, but there is still considerable debate.
- Electrolyte Imbalances - Studies from UK racing stables have indicated that chronic sodium and/or potassium deficiencies may be involved in chronic equine rhabdomyelosis. This is difficult to detect routinely so a special urine test is used to assess levels.
- Viral Causes - Muscle involvement following viral disease (e.g. influenza) has been investigated but the associated muscle pain (myalgia) is generally considered to be a separate and distinct disease process.
Clinical Signs Signs vary widely depending on the extent of muscle damage. - Mild cases simply involve stiffness and shuffling hindlimb gait. There may be pain over the gluteal muscles (hindquarters). This form is more common in horses receiving only small amounts of exercise.
- Some cases are a result of stressful triggering factors. This is common in younger horses and will often have a behavioural component.
- In some very mild cases, poor performance is the only manifestation of the disease.
- Severe cases may include signs of severe pain with sweating, increased pulse rate, increased respiration rate and reluctance to move. There may be hard and painful locomotor muscles, red urine (due to the presence of muscle breakdown products) and even recumbency. This often transpires in horses during endurance training where significant fluid and electrolyte alterations occur.
Diagnostic Tests Diagnosis is sometimes based on clinical signs alone but with mild cases it is important to carry out further tests. These may include: - Serum Muscle Enzymes - the blood can be tested to look for abnormal values of these substances, which are produced when muscle has been damaged.
- Urinary Electrolyte Testing - Can be used to detect electrolyte abnormalities, which can predispose to the disease and it can also be used to monitor management and treatment.
- Urinary Testing - like the blood, the urine can be tested for products associated with the breakdown of muscle tissue.
- Muscle biopsy - this involves a small sample of muscle which is removed under local anaesthesia and sedation and examined under the microscope for abnormalities.
Prevention of Azoturia
Regular exercise with warming up and cooling down periods together with only the necessary amount of feed will help to prevent Azoturia. Treatment of Azoturia MILD CASES- Thiamine, vitamin E and selenium have been used widely in practice, and some evidence suggests they are useful in improving recovery.
- Non-steroidal anti-inflammatory drugs (NSAIDs) such as flunixin and phenylbutazone may be used to control the pain
- Some drugs, such as Acepromazine (ACP) can be used to increase blood flow and alleviate muscle spasm.
- 3-4 days box rest is indicated, followed by a gradual return to exercise.
- Walking mildly affected horses is sometimes effective, and most will recover without further treatment.
- Lowering the training intensity and decreasing the grain in the diet is also very useful.
SEVERE CASES- Fluid therapy is vital to relieve shock and to prevent renal failure. This can be oral, but in very severe cases, will be used intravenously.
- Steroids may be used during initial acute stages
- NSAIDs may once again be indicated to relieve pain.
- If there is severe pain, other, stronger painkillers may be used.
CHRONIC INTERMITTENT CASES- Substances which alter the metabolism of minerals in the blood may be used.
- If urine electrolyte tests indicate very low values of Sodium or Potassium, supplementation may be required.
Tags: Article Horse Azoturia in Horse Azoturia Monday Morning Disease Tying-Up Azoturia Paralytic Myoglobinuria Myositis Setfast
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